ToxPi

Abstract

ToxPi GUI (Toxicological Priority Index graphical user interface) is a flexible prioritization support software tool based on the "Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data” article by David M. Reif et al. that incorporates chemical’s bioactivity profiles, inferred toxicity pathways, dose estimates, exposure data, chemical structural descriptors, etc.

Areas of application:

  • Calculate the comprehensive toxicity potential of a chemical
  • Provide a visual that represents relative contribution of each data domain
  • Enable a new weight-of-evidence framework for diverse prioritization
  • Numerically integrate multiple information domains
  • Incorporate existing knowledge, prioritization schemes and different types of data
  • Provide multivariate of toxicity relative to any set of chemicals
  • Customize components for diverse prioritization tasks
  • Estimate uncertainty in various indices calculated from the underlying data
  • Provide complete transparency in deriving the toxicity score

Download software v 1.3 (Windows executable file)

Download software v 1.3 (Java JAR file)

Download user manual v 1.3

Show previous versions

Example data

Right Click the link to the Example data file with 6 slices, custom types, colors and scaling types (NOTE: WORKS since version 1.2) and select "Save As" from the options.

Right Click the link to the EXAMPLE data biomedical 4 custom slices and select "Save As" from the options.

Right Click the link to the Example data file with 3 slices and custom types and select "Save As" from the options.

Right Click the link to the Example data file with 3 weighted slices and select "Save As" from the options.

Right Click the link to the Example data file with 4 slices and select "Save As" from the options.

Right Click the link to the Example data file with 6 slices and select "Save As" from the options.

Sample data

Right Click the link to the Assays data from EPA toxminer database version 17 and select "Save As" from the options.

Right Click the link to the Chemical properties data from EPA toxminer database version 17 and select "Save As" from the options.

Right Click the link to the Pathway data from EPA toxminer database version 17 and select "Save As" from the options.