Bell Tower at the University of North Carolina
PROJECT 1
Predictive modeling of chemical-perturbed regulatory networks in systems toxicology
Cross-talk and co-regulation among nuclear receptors. Designation of nodes and edges is indicated at the bottom of the figure (from Woods et al., 2007).
PROJECT 2
Toxico-genetic modeling: Population-wide predictions from toxicity profiling
A strategy to detect the eQTL modules that are mediated by transcription factor activities (adapted from Sun et al., 2007).
PROJECT 3
Development of validated and predictive Quantitative Structure-Toxicity Relationship models that employ both chemical and biological descriptors of molecular structures and take into account genetic diversity between individuals.
Combining chemical and biological descriptors in QSAR modeling of chemical carcinogenicity.
