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PROJECT 1
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| Predictive modeling of chemical-perturbed regulatory networks in systems toxicology | |
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Cross-talk and co-regulation among nuclear receptors. Designation of nodes and edges is indicated at the bottom of the figure (from Woods et al., 2007). |
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PROJECT 2 |
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| Toxico-genetic modeling: Population-wide predictions from toxicity profiling | |
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A strategy to detect the eQTL modules that are mediated by transcription factor activities (adapted from Sun et al., 2007). |
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PROJECT 3 |
| Development of validated and predictive Quantitative Structure-Toxicity Relationship models that employ both chemical and biological descriptors of molecular structures and take into account genetic diversity between individuals. |
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Combining chemical and biological descriptors in QSAR modeling of chemical carcinogenicity. |
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